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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MSH6
All Species:
30.61
Human Site:
S1251
Identified Species:
48.1
UniProt:
P52701
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52701
NP_000170.1
1360
152786
S1251
L
F
S
T
H
Y
H
S
L
V
E
D
Y
S
Q
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001113749
1360
152750
S1251
L
F
S
T
H
Y
H
S
L
V
E
D
Y
S
Q
Dog
Lupus familis
XP_531814
1283
145094
E1195
G
H
M
A
C
M
V
E
N
E
C
E
D
P
S
Cat
Felis silvestris
Mouse
Mus musculus
P54276
1358
151058
S1249
L
F
S
T
H
Y
H
S
L
V
E
D
Y
S
K
Rat
Rattus norvegicus
XP_002726765
1361
151628
S1252
L
F
S
T
H
Y
H
S
L
V
E
D
Y
S
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419359
1466
164165
S1357
L
F
S
T
H
Y
H
S
L
V
E
D
Y
S
G
Frog
Xenopus laevis
NP_001089247
1340
149481
S1233
L
F
S
T
H
Y
H
S
L
V
E
D
H
S
H
Zebra Danio
Brachydanio rerio
NP_878280
1369
153213
S1260
L
F
S
T
H
Y
H
S
L
V
E
D
H
V
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUM0
1190
133117
E1105
D
N
A
D
P
T
Q
E
T
V
T
F
L
Y
K
Honey Bee
Apis mellifera
XP_392346
1120
127429
M1035
K
K
I
T
L
A
H
M
A
C
M
V
E
N
E
Nematode Worm
Caenorhab. elegans
NP_491163
1186
133609
K1101
H
M
K
C
V
V
D
K
E
N
N
E
D
P
T
Sea Urchin
Strong. purpuratus
XP_797647
1335
149141
S1227
L
F
S
T
H
Y
H
S
L
V
E
E
F
S
H
Poplar Tree
Populus trichocarpa
XP_002320307
1288
142120
K1199
L
R
P
G
A
C
P
K
S
Y
G
V
N
V
A
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04716
1324
146779
R1200
F
F
S
T
H
Y
H
R
L
S
V
D
Y
Q
T
Baker's Yeast
Sacchar. cerevisiae
Q03834
1242
140062
D1157
G
I
S
K
E
I
I
D
N
A
Q
I
A
A
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.3
88.1
N.A.
85.8
86.4
N.A.
N.A.
64.2
66.5
60
N.A.
39
41.2
34.4
48.6
Protein Similarity:
100
N.A.
98.6
91.3
N.A.
92.1
92.8
N.A.
N.A.
75.4
79.9
74.9
N.A.
57.6
58
52.7
66.6
P-Site Identity:
100
N.A.
100
0
N.A.
93.3
93.3
N.A.
N.A.
93.3
86.6
86.6
N.A.
6.6
13.3
0
80
P-Site Similarity:
100
N.A.
100
6.6
N.A.
100
100
N.A.
N.A.
93.3
93.3
93.3
N.A.
20
26.6
6.6
93.3
Percent
Protein Identity:
36.1
N.A.
N.A.
33.2
29
N.A.
Protein Similarity:
52
N.A.
N.A.
51.4
49.1
N.A.
P-Site Identity:
6.6
N.A.
N.A.
60
6.6
N.A.
P-Site Similarity:
6.6
N.A.
N.A.
60
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
7
7
7
0
0
7
7
0
0
7
7
7
% A
% Cys:
0
0
0
7
7
7
0
0
0
7
7
0
0
0
0
% C
% Asp:
7
0
0
7
0
0
7
7
0
0
0
54
14
0
7
% D
% Glu:
0
0
0
0
7
0
0
14
7
7
54
20
7
0
7
% E
% Phe:
7
60
0
0
0
0
0
0
0
0
0
7
7
0
0
% F
% Gly:
14
0
0
7
0
0
0
0
0
0
7
0
0
0
7
% G
% His:
7
7
0
0
60
0
67
0
0
0
0
0
14
0
14
% H
% Ile:
0
7
7
0
0
7
7
0
0
0
0
7
0
0
0
% I
% Lys:
7
7
7
7
0
0
0
14
0
0
0
0
0
0
20
% K
% Leu:
60
0
0
0
7
0
0
0
60
0
0
0
7
0
0
% L
% Met:
0
7
7
0
0
7
0
7
0
0
7
0
0
0
0
% M
% Asn:
0
7
0
0
0
0
0
0
14
7
7
0
7
7
0
% N
% Pro:
0
0
7
0
7
0
7
0
0
0
0
0
0
14
0
% P
% Gln:
0
0
0
0
0
0
7
0
0
0
7
0
0
7
20
% Q
% Arg:
0
7
0
0
0
0
0
7
0
0
0
0
0
0
0
% R
% Ser:
0
0
67
0
0
0
0
54
7
7
0
0
0
47
7
% S
% Thr:
0
0
0
67
0
7
0
0
7
0
7
0
0
0
14
% T
% Val:
0
0
0
0
7
7
7
0
0
60
7
14
0
14
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
60
0
0
0
7
0
0
40
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _